gdisc: Cancer/Drug/Gene-CNV Analysis

GDISC: Gene-Drug Interactions for Survival in Cancer

Search Method 1 (Query):

Search Method 2 (Significant Genes):

Cancer Name:
Drug Name:
Gene Name:

Cancer	Drug	#Patients	#Gene
BLCA	Cisplatin	79	0
BLCA	Gemcitabine	90	0
BRCA	Anastrozole	240	216
BRCA	Carboplatin	30	218
BRCA	Cyclophosphamide	506	28
BRCA	Docetaxel	189	104
BRCA	Doxorubicin	357	74
BRCA	Epirubicin	42	307
BRCA	Exemestane	47	589
BRCA	Fluorouracil	101	161
BRCA	Letrozole	73	0
BRCA	Paclitaxel	228	0
BRCA	Tamoxifen	252	55
BRCA	Trastuzumab	72	13
CESC	Cisplatin	119	53
COAD	Bevacizumab	33	0
COAD	Capecitabine	31	250
COAD	Fluorouracil	129	216
COAD	Irinotecan	31	0
COAD	Leucovorin	116	0
COAD	Oxaliplatin	112	1
DLBC	Cyclophosphamide	40	0
DLBC	Doxorubicin	40	18
DLBC	Rituximab	32	0
DLBC	Vincristine	41	0
GBM	Temozolomide	40	14
HNSC	Carboplatin	62	312
HNSC	Cetuximab	35	41
HNSC	Cisplatin	102	131
HNSC	Paclitaxel	47	120
LGG	Bevacizumab	49	2094
LGG	Lomustine	43	110
LGG	Temozolomide	258	3086
LUAD	Carboplatin	75	0
LUAD	Cisplatin	84	39
LUAD	Paclitaxel	44	412
LUAD	Pemetrexed	59	33
LUSC	Carboplatin	58	29
LUSC	Cisplatin	72	0
LUSC	Docetaxel	33	41
LUSC	Gemcitabine	36	186
LUSC	Vinorelbine	43	63
MESO	Cisplatin	35	6
MESO	Pemetrexed	38	0
OV	Bevacizumab	55	134
OV	Carboplatin	472	0
OV	Cisplatin	155	16
OV	Docetaxel	115	0
OV	Doxorubicin	151	0
OV	Gemcitabine	137	0
OV	Paclitaxel	466	0
OV	Tamoxifen	32	24
OV	Topotecan	117	0
PAAD	Fluorouracil	36	416
PAAD	Gemcitabine	108	0
PRAD	Leuprolide	51	49
READ	Fluorouracil	60	0
READ	Leucovorin	48	0
READ	Oxaliplatin	43	0
SARC	Docetaxel	36	256
SARC	Doxorubicin	40	192
SARC	Gemcitabine	41	261
SKCM	NOS	39	0
STAD	Capecitabine	36	0
STAD	Cisplatin	53	0
STAD	Epirubicin	33	0
STAD	Fluorouracil	126	23
STAD	Leucovorin	52	0
TGCT	Bleomycin	53	0
TGCT	Cisplatin	53	0
TGCT	Etoposide	54	0
THCA	Levothyroxine	38	0
UCEC	Carboplatin	164	0
UCEC	Doxorubicin	32	248
UCEC	Paclitaxel	160	0
UCS	Carboplatin	30	16
UCS	Paclitaxel	31	1

Search Method 3 (Number of Samples):

Click Sample Number in the table.

		BRCA	OV	GBM	LGG	DLBC	THCA	PRAD	TGCT	HNSC	SARC	MESO	BLCA	SKCM	CESC	UCEC	UCS	LUAD	LUSC	COAD	READ	PAAD	STAD

	Bevacizumab	14	55	4	49	0	0	0	0	1	2	1	0	1	1	5	1	12	0	33	10	0	0
	Cyclophosphamide	506	29	0	3	40	0	0	0	0	0	0	0	1	1	2	2	1	3	0	0	1	7
	Doxorubicin	357	151	0	0	40	2	0	0	0	40	2	15	1	2	32	3	0	2	0	0	1	2
	Docetaxel	189	115	0	0	0	0	3	0	14	36	0	5	0	0	8	3	23	33	0	0	1	6
	Paclitaxel	228	466	0	0	0	0	0	1	47	0	0	11	5	14	160	31	44	28	0	0	5	5
	NOS	20	13	1	1	1	0	1	0	18	3	9	9	39	1	5	0	16	12	2	5	8	4
	Carboplatin	30	472	2	8	3	0	1	3	62	1	14	23	4	15	164	30	75	58	0	0	1	5
	Cisplatin	2	155	0	0	2	0	0	53	102	3	35	79	6	119	20	7	84	72	0	1	2	53
	Gemcitabine	8	137	0	0	1	0	1	1	2	41	9	90	2	3	5	1	25	36	0	1	108	0
	Etoposide	1	15	0	12	8	0	0	54	0	1	0	3	0	0	0	0	15	14	0	1	0	22
	Cetuximab	0	4	0	0	0	0	0	0	35	0	0	0	0	1	0	0	0	2	15	0	0	1
	Fluorouracil	101	1	0	0	0	0	0	0	6	0	0	1	0	7	0	0	0	0	129	60	36	126
	Capecitabine	15	5	6	2	0	0	0	0	4	0	0	0	0	0	0	0	0	0	31	13	12	36
	Irinotecan	0	1	5	21	0	0	0	0	1	0	0	0	0	0	0	0	2	1	31	8	12	3
	Leucovorin	0	1	0	0	1	0	0	0	0	0	0	0	0	0	0	0	0	0	116	48	17	52
	Oxaliplatin	0	8	0	0	0	0	0	1	2	0	0	1	0	0	0	0	0	1	112	43	20	29
	Pemetrexed	1	1	0	0	0	0	0	0	4	1	38	0	0	0	0	0	59	6	0	0	0	0
	Vinorelbine	7	25	0	0	1	0	0	0	0	0	1	1	0	0	0	0	23	43	0	0	0	0
	Bleomycin	0	0	0	0	3	0	0	53	0	0	0	0	1	2	0	0	0	0	0	0	0	0
	Topotecan	0	117	0	1	0	0	0	0	0	0	0	0	0	2	5	0	1	1	0	0	0	0
	Vincristine	2	1	2	20	41	0	0	0	0	0	0	0	0	1	0	0	0	4	0	0	0	1
	Temozolomide	0	0	40	258	0	0	0	0	0	1	0	0	3	0	0	0	0	1	0	0	0	0
	Lomustine	0	0	7	43	0	0	0	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0
	Procarbazine	0	0	3	27	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Tamoxifen	252	32	3	8	0	0	0	0	0	2	0	0	3	0	4	0	0	0	0	0	0	0
	Levothyroxine	0	0	0	0	0	38	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Prednisone	1	0	0	0	29	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Rituximab	1	0	0	0	32	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Epirubicin	42	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	33
	Leuprolide	7	1	0	0	0	0	51	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
	Exemestane	47	1	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0	0
	Trastuzumab	72	2	0	0	0	0	0	0	0	0	0	0	1	0	0	0	0	0	0	0	0	0
	Anastrozole	240	4	0	0	0	0	0	0	0	0	0	0	0	0	2	0	0	0	0	0	0	0
	Letrozole	73	8	0	0	0	0	0	0	0	2	0	0	0	0	1	0	0	0	0	0	0	0

Lung squamous cell carcinoma (LUSC) / TPM4 / Cisplatin

#Patients	#Tests	Treashold	P value	Raw P
142	4397	0.05	1.00e+00	6.30e-01

#Patients	Dec/Nor	Nor/Inc	Inc/Dec
140	2.00e-02	1.18e-02	4.39e-01

#Patients	#Tests	Treashold	P value	Raw P
72	2654	0.05	1.00e+00	3.65e-01

#Patients	Dec/Nor	Nor/Inc	Inc/Dec
71	3.48e-02	2.53e-01	7.24e-01

Nomemclature of the tables:

#Tests

Number of unique Copy Number Variabtion (CNV) patterns among the corresponding Patients.

P value

Bonferroni corrected P value ( Raw P value * #Tests ).

Dec/Nor, Nor/Inc, Inc/Dec

P value of t-tests between the Gene expressions of Decreased, Normal, Increased CNV patient groups.