GDISC: Gene-Drug Interactions for Survival in Cancer

Search Method 1 (Query):

Search Method 2 (Significant Genes):

Cancer Name:
Drug Name:
Gene Name:
Cancer Drug #Patients #Gene
BLCA Cisplatin 79 0
BLCA Gemcitabine 90 0
BRCA Anastrozole 240 216
BRCA Carboplatin 30 218
BRCA Cyclophosphamide 506 28
BRCA Docetaxel 189 104
BRCA Doxorubicin 357 74
BRCA Epirubicin 42 307
BRCA Exemestane 47 589
BRCA Fluorouracil 101 161
BRCA Letrozole 73 0
BRCA Paclitaxel 228 0
BRCA Tamoxifen 252 55
BRCA Trastuzumab 72 13
CESC Cisplatin 119 53
COAD Bevacizumab 33 0
COAD Capecitabine 31 250
COAD Fluorouracil 129 216
COAD Irinotecan 31 0
COAD Leucovorin 116 0
COAD Oxaliplatin 112 1
DLBC Cyclophosphamide 40 0
DLBC Doxorubicin 40 18
DLBC Rituximab 32 0
DLBC Vincristine 41 0
GBM Temozolomide 40 14
HNSC Carboplatin 62 312
HNSC Cetuximab 35 41
HNSC Cisplatin 102 131
HNSC Paclitaxel 47 120
LGG Bevacizumab 49 2094
LGG Lomustine 43 110
LGG Temozolomide 258 3086
LUAD Carboplatin 75 0
LUAD Cisplatin 84 39
LUAD Paclitaxel 44 412
LUAD Pemetrexed 59 33
LUSC Carboplatin 58 29
LUSC Cisplatin 72 0
LUSC Docetaxel 33 41
LUSC Gemcitabine 36 186
LUSC Vinorelbine 43 63
MESO Cisplatin 35 6
MESO Pemetrexed 38 0
OV Bevacizumab 55 134
OV Carboplatin 472 0
OV Cisplatin 155 16
OV Docetaxel 115 0
OV Doxorubicin 151 0
OV Gemcitabine 137 0
OV Paclitaxel 466 0
OV Tamoxifen 32 24
OV Topotecan 117 0
PAAD Fluorouracil 36 416
PAAD Gemcitabine 108 0
PRAD Leuprolide 51 49
READ Fluorouracil 60 0
READ Leucovorin 48 0
READ Oxaliplatin 43 0
SARC Docetaxel 36 256
SARC Doxorubicin 40 192
SARC Gemcitabine 41 261
SKCM NOS 39 0
STAD Capecitabine 36 0
STAD Cisplatin 53 0
STAD Epirubicin 33 0
STAD Fluorouracil 126 23
STAD Leucovorin 52 0
TGCT Bleomycin 53 0
TGCT Cisplatin 53 0
TGCT Etoposide 54 0
THCA Levothyroxine 38 0
UCEC Carboplatin 164 0
UCEC Doxorubicin 32 248
UCEC Paclitaxel 160 0
UCS Carboplatin 30 16
UCS Paclitaxel 31 1

Search Method 3 (Number of Samples):

Pancreatic adenocarcinoma (PAAD) / SDK1 / Gemcitabine

#Patients #Tests Treashold P value Raw P
120 1997 0.05 1.00e+00 8.53e-01
#Patients Dec/Nor Nor/Inc Inc/Dec
116 5.95e-01 6.04e-01 1.63e-02
#Patients #Tests Treashold P value Raw P
108 1852 0.05 1.00e+00 9.37e-01
#Patients Dec/Nor Nor/Inc Inc/Dec
104 6.27e-01 5.86e-01 1.95e-02

Nomemclature of the tables:

#Tests

Number of unique Copy Number Variabtion (CNV) patterns among the corresponding Patients.

P value

Bonferroni corrected P value ( Raw P value * #Tests ).

Dec/Nor, Nor/Inc, Inc/Dec

P value of t-tests between the Gene expressions of Decreased, Normal, Increased CNV patient groups.